1.    Viruses are not strictly considered to be living cells.
– Describe the general structure of viruses.
– Explain why viruses are not considered living cells.
(2.5 marks–LO3)
2.    Label the diagram to identify the different steps of generic viral replication in the host cell.
            (1.5 mark–LO3)

3.    Complete the paragraph by filling in the blanks:
Human immunodeficiency virus (HIV) is especially harmful as it targets…………cells which are lymphocytes that can be differentiated by having the CD4 protein on their cell membrane. When these specific cells are activated by an antigen they release cytokines to help other …. cells, which are responsible for cellular immunity, and …. cells, which are responsible for humoral immunity, to produce immune response.
A person infected with HIV is classified as having acquired immunodeficiency syndrome (AIDS) when……………………………………………………………………………………………………………………. ………………………………………………………………………………………………………………………………………..
            (2 marks–LO1).
4.    Explain in detail how the viral proteins are synthesised by the host cell, from viral DNA incorporated in the host cell genome (steps 3 & 4 in the diagram). (8 marks–LO1)
5.    Antigenic variation is a challenge that faces vaccine development.
–    Explain how vaccination prevents a general epidemic of a viral diseases.
–    Explain the difference between antigenic drift and antigenic shift.
–    Explain why it is difficult to develop vaccines for viruses that are capable of antigenic variation.
(6 marks–LO3)

Instructions:
    The written assignment will assesses your learning and understanding of physiology (LO 1), microbiology (LO 3) and the academic standard of writing and referencing (LO 4).
    The lectures delivered in weeks 2, 3 and 4 will provide you with most of the content. You will also need to read the required textbook, and a microbiology textbook (see earlier recommendation on page 8).
    Make your own notes and provided answers in your own words to all of the following five questions (see page 11).
YOU MUST!!!!!!!!!!!!
    Word limit 1000 words (minimum 900 words – maximum 1100 words).
    A minimum of two references should be used to support your writing; one for anatomy & physiology and another for microbiology. In-text citations of your references are required and you must also attach a separate reference page using APA 6th formatting.
    integrates knowledge of anatomy and physiology to the maintenance of normal health and function
    Comprehensive and in-depth examination of the role of micro-organisms in health and disease
Present work at the appropriate academic standard: Mostly accurate use of terminology (spelling and grammar). Mostly accurate acknowledgement of sources of information; Sources are credible and of recognized academic quality Assignment instructions have been followed

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